Respostas cardiovasculares a diferentes formulações do suplemento OxyElite Pro

Paulo Vinicios Camuzi Zovico, Brunella Faro Klippel, Leandro dos Santos, Daniel Ventura Dias, Valério Garrone Barauna

Resumo


Introdução: OxyElite Pro (OEP) é um suplemento vendido com o objetivo de aumentar o metabolismo e melhorar o desempenho físico. Este suplemento contém como principais ingredientes a cafeína e o 1,3 dimetilamilamina (DMAA) que podem atuar como estimulantes. Diversos efeitos adversos, principalmente no sistema cardiovascular, têm sido relatados após o consumo de suplementos contendo DMAA e cafeína, entretanto, estes efeitos são relacionados a doses altas ou desconhecidas destes suplementos e/ou a outros fatores. Objetivo: Avaliar o efeito da suplementação aguda do OEP com e sem DMAA sobre as respostas hemodinâmicas de ratos Wistar. Materiais e métodos: Ratos Wistar machos foram divididos em quatro grupos experimentais: controle, OEP-DMAA, OEP+DMAA e 2x OEP+DMAA. Todos os grupos foram submetidos a uma única administração aguda do OEP para avaliação das respostas hemodinâmicas. Resultados: A ingestão de 2x OEP+DMAA apresentou efeitos prolongados sobre a PAM, PAS, PAD, FC e DP ao longo do tempo que persistiu até 90 minutos pós-ingestão. Já a ingestão de OEP+DMAA apresentou aumento transitório sobre as respostas hemodinâmicas no tempo de 5 minutos, voltando aos valores basais rapidamente após a ingestão. A ingestão de OEP+DMAA apresentou aumentos mais prolongados apenas sobre a FC e DP com 30 minutos permanecendo até 90 minutos após a ingestão. Nenhum efeito foi observado nas respostas hemodinâmicas após o uso do suplemento OEP-DMAA. Conclusão: A suplementação com OEP contendo DMAA foi capaz de aumentar as respostas hemodinâmicas de ratos Wistar com efeito mais prolongados quando administrado em doses 2x OEP+DMAA.

 

ABSTRACT 

Cardiovascular responses to different formulations of the OxyElite Pro supplement

Background: OxyElite Pro (OEP) is a supplement sold with the goal of increase metabolism and improving physical performance. This supplement contains as its main ingredients caffeine and 1,3-dimethylamylamine (DMAA) that can act as stimulants. Several adverse effects, mainly in the cardiovascular system, have been reported after of consumption supplements containing DMAA and caffeine, however, these effects are related to overdose or unknown doses of these supplements and / or other factors. Objective: Evaluate the acute supplementation of the OEP with and without DMAA on hemodynamic responses in Wistar rats.  Materials and methods: Male Wistar rats were divided into four experimental groups: control, OEP-DMAA, OEP+DMAA and 2x OEP+DMAA. All groups submitted a single acute administration of OEP to evaluate hemodynamic responses. Results: Ingestion of 2x OEP+DMAA produced prolonged effects on MBP, SBP, DBP, HR and DP over time and that persisted up to 90 minutes after ingestion. On the other hand, the ingestion of OEP+DMAA presented a transient increase on hemodynamic responses in the time of 5 minutes, returning to the basal values rapidly after ingestion. Intake of OEP+DMAA showed longer increases only on HR and DP with 30 minutes remaining up to 90 minutes after ingestion. No effect was observed on hemodynamic responses after the use of the OEP-DMAA supplement. Conclusion: DMAA-containing OEP supplementation was able to increase hemodynamic responses of Wistar rats with a longer effect when administered at 2x OEP + DMAA doses.


Palavras-chave


Suplemento alimentar; Respostas hemodinâmicas; DMAA; Cafeína

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Referências


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