Respostas cardiovasculares a diferentes formulações do suplemento OxyElite Pro

  • Paulo Vinicios Camuzi Zovico Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo (UFES), Vitória-ES, Brasil
  • Brunella Faro Klippel Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo (UFES), Vitória-ES, Brasil
  • Leandro dos Santos Universidade Federal Rural de Pernambuco (UFPE), Unidade Acadêmica de Serra Talhada, Serra Talhada-PE, Brasil
  • Daniel Ventura Dias Universidade Federal de Pampa (UNIPAMPA), Uruguaiana-RS, Brasil
  • Valério Garrone Barauna Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo (UFES), Vitória-ES, Brasil
Palavras-chave: Suplemento alimentar, Respostas hemodinâmicas, DMAA, Cafeína


Introdução: OxyElite Pro (OEP) é um suplemento vendido com o objetivo de aumentar o metabolismo e melhorar o desempenho físico. Este suplemento contém como principais ingredientes a cafeína e o 1,3 dimetilamilamina (DMAA) que podem atuar como estimulantes. Diversos efeitos adversos, principalmente no sistema cardiovascular, têm sido relatados após o consumo de suplementos contendo DMAA e cafeína, entretanto, estes efeitos são relacionados a doses altas ou desconhecidas destes suplementos e/ou a outros fatores. Objetivo: Avaliar o efeito da suplementação aguda do OEP com e sem DMAA sobre as respostas hemodinâmicas de ratos Wistar. Materiais e métodos: Ratos Wistar machos foram divididos em quatro grupos experimentais: controle, OEP-DMAA, OEP+DMAA e 2x OEP+DMAA. Todos os grupos foram submetidos a uma única administração aguda do OEP para avaliação das respostas hemodinâmicas. Resultados: A ingestão de 2x OEP+DMAA apresentou efeitos prolongados sobre a PAM, PAS, PAD, FC e DP ao longo do tempo que persistiu até 90 minutos pós-ingestão. Já a ingestão de OEP+DMAA apresentou aumento transitório sobre as respostas hemodinâmicas no tempo de 5 minutos, voltando aos valores basais rapidamente após a ingestão. A ingestão de OEP+DMAA apresentou aumentos mais prolongados apenas sobre a FC e DP com 30 minutos permanecendo até 90 minutos após a ingestão. Nenhum efeito foi observado nas respostas hemodinâmicas após o uso do suplemento OEP-DMAA. Conclusão: A suplementação com OEP contendo DMAA foi capaz de aumentar as respostas hemodinâmicas de ratos Wistar com efeito mais prolongados quando administrado em doses 2x OEP+DMAA.



Cardiovascular responses to different formulations of the OxyElite Pro supplement

Background: OxyElite Pro (OEP) is a supplement sold with the goal of increase metabolism and improving physical performance. This supplement contains as its main ingredients caffeine and 1,3-dimethylamylamine (DMAA) that can act as stimulants. Several adverse effects, mainly in the cardiovascular system, have been reported after of consumption supplements containing DMAA and caffeine, however, these effects are related to overdose or unknown doses of these supplements and / or other factors. Objective: Evaluate the acute supplementation of the OEP with and without DMAA on hemodynamic responses in Wistar rats.  Materials and methods: Male Wistar rats were divided into four experimental groups: control, OEP-DMAA, OEP+DMAA and 2x OEP+DMAA. All groups submitted a single acute administration of OEP to evaluate hemodynamic responses. Results: Ingestion of 2x OEP+DMAA produced prolonged effects on MBP, SBP, DBP, HR and DP over time and that persisted up to 90 minutes after ingestion. On the other hand, the ingestion of OEP+DMAA presented a transient increase on hemodynamic responses in the time of 5 minutes, returning to the basal values rapidly after ingestion. Intake of OEP+DMAA showed longer increases only on HR and DP with 30 minutes remaining up to 90 minutes after ingestion. No effect was observed on hemodynamic responses after the use of the OEP-DMAA supplement. Conclusion: DMAA-containing OEP supplementation was able to increase hemodynamic responses of Wistar rats with a longer effect when administered at 2x OEP + DMAA doses.


-Archer, J.R.H.; Dargan, P.I.; Lostia, A.M.; Walt, J.; Henderson, K.; Drake N.; Sharma, S.; Wood, D.M.; Walker, C.J.; Kicman, A.T. Running an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA). Drug Testing Analysis. Vol. 7. Num. 5. 2015. p. 433-438.

-Armstrong, M. Atrial Fibrillation with Rapid Ventricular Response following use of Dietary Supplement Containing 1,3 Dimethylamylamine and Caffeine. Journal of Special Operations Medicine. Vol. 12. Num. 4. 2012. p. 1-4.

-Bloomer, R.J.; Farney, T.M.; Harvey, I.C.; Alleman, R.J. Safety profile of caffeine and 1,3-dimethylamylamine supplementation in healthy men. Human & Experimental Toxicology. Vol. 32. Num. 11. 2013. p. 1126-1136.

-Bloomer, R.J.; Harvey, I.C.; Farney, T.M.; Bell, Z.W.; Canale, R.E. Effects of 1,3-dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women. The Physician and Sports medicine. Vol. 39. Num. 3. 2011a. p. 111-120.

-Bloomer, R.J.; McCarthy, C.G.; Farney, T.M.; Harvey, I.C. Effect of Caffeine and 1,3-Dimethylamylamine on Exercise Performance and Blood Markers of Lipolysis and Oxidative Stress in Trained Men and Women. Journal of Caffeine Research. Vol. 1. Num. 3. 2011b. p. 169-177.

-Carpenter, D. Strengthen and stabilize the FDA. Nature. Vol. 485. 2012. p. 169-170.

-Chatham-Stephens, K.; Taylor, E.; Chang, A.; Peterson, A.; Daniel, J.; Martin, C.; Deuster, P.; Noe, R.; Kieszak, S.; Schier, J.; Klontz, K.; Lewis, L. Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE ProTM - United States, 2013. Drug Testing and Analysis. Vol. 9. Num. 1. 2017. p. 68-74.

-Eliason, M.J.; Eichner, A. Cancio, A.; Bestervelt, L.; Adams, B.D.; Deuster, P.A. Case reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA). Military Medicine. Vol. 177. Num. 12. 2012. p. 1455-1459.

-Eudy, A.E.; Gordon, L.L.; Hockaday, B.C.; Lee, D.A.; Lee, V.; Luu, D.; Martinez, C. A.; Ambrose, P. J. Efficacy and safety of ingredients found in preworkout supplements. American Journal of Health System Pharmacy. Vol. 70. Num. 7. 2013. p. 577-588.

-Farney, T.M.; McCarthy, C.G.; Canale, R.E.; Allman, R.J.; Bloomer, R.J. Hemodynamic and hematologic profile of healthy adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutrition and Metabolic Insights. Vol. 5. 2012. p. 1-12.

-FDA. DMAA in Dietary Supplements. Available from: 2013.

-Foley, S.; Butlin, E.; Shields, W.; Lacey, B. Experience with OxyELITE pro and acute liver injury in active duty service members. Digestive Diseases and Sciences. Vol. 59. Num. 12. 2014. p. 3117-3121.

-Forrester, M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Human & Experimental Toxicology. Vol. 32. Num. 1. 2013. p.18-23.

-García-Cortés, M.; Robles-Díaz, M.; Ortega-Alonso, A.; Medina-Caliz, I.; Andrade, R.J. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. International Journal of Molecular Sciences. Vol. 17. Num. 4. 2016. p. 537-560.

-Gee, P.; Jackson, S.; Easton, J. Another bitter pill: a case of toxicity from DMAA party pills. The New Zealand Medical Journal. Vol. 123. Num. 1327. 2010. p. 124-127.

-Gee, P.; Tallon, C.; Long, N.; Moore, G.; Boet, R.; Jackson, S. Use of recreational drug 1,3 Dimethylamylamine (DMAA) [corrected] associated with cerebral hemorrhage. Annals of Emergency Medicine. Vol. 60. Num. 4. 2012. p. 431-434.

-Geller, A.I.; Shehab, N.; Weidle, N.J.; Lovegrove, M.C.; Wolpert, B.J.; Timbo, B.B.; Mozersky, R. P.; Budnitz, D. S. Emergency Department Visits for Adverse Events Related to Dietary Supplements. The New England Journal of Medicine. Vol. 373. Num. 16. 2015. p. 1531-1540.

-Johnston, D.I.; Chang, A.; Viray, M.; Chatham-Stephens, K.; He, H.; Taylor, E.; Wong, L.L.; Schier, J.; Martin, C.; Fabricant, D.; Salter, M.; Lewis, L.; Parky, S. Y. Hepatotoxicity associated with the dietary supplement OxyELITE ProTM - Hawaii, 2013. Drug Testing and Analysis. Vol. 8. Num. 3-4. 2015. p. 319-327.

-Karnatovskaia, L.V.; Leoni, J.C.; Freeman, M.L. Cardiac arrest in a 21-year-old man after ingestion of 1,3-DMAA-containing workout supplement. Clinical Journal of Sport Medicine. Vol. 25. Num. 1. 2015. p. 23-25.

-Klippel, B.F.; Duemke, L.B.; Leal, M.A.; Friques, A.G.F.; Dantas, E.M.; Dalvi, R.F.; Gava, A.L.; Pereira, T.M.; Andrade, T.U.; Meyrelles, S.S.; Campagnaro, B.P.; Vasquez, E. C. Effects of Kefir on the Cardiac Autonomic Tones and Baroreflex Sensitivity in Spontaneously Hypertensive Rats. Frontiers in Physiology. Vol. 7. 2016. p. 211-223.

-McCarthy, C.G.; Canale, R.E.; Alleman, R.J.; Reed, J.P.; Bloomer, R.J. Biochemical and anthropometric effects of a weight loss dietary supplement in healthy men and women. Nutrition and Metabolic Insights. Vol. 5. 2012a. p. 13-22.

-McCarthy, C.G.; Farney, T.M.; Canale, R.E.; Alleman, R.J.; Bloomer, R.J. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutrition and Metabolic Insights. Vol. 5. 2012b. p. 23-31.

-Nurminen, M.L.; Niittynen, L.; Korpela, R.; Vapaatalo, H. Coffee, caffeine and blood pressure: a critical review. European Journal of Clinical Nutrition. Vol. 53. Num. 11. 1999. p. 831-839.

-Rodricks, J.V.; Lumpkin, M.H.; Schilling, B.K. Pharmacokinetic data distinguish abusive versus dietary supplement uses of 1,3-dimethylamylamine. Annals of Emergency Medicine. Vol. 61. Num. 6. 2013. p. 718-789.

-Roytman, M.M.; Pörzgen, P.; Lee, C.L.; Huddleston, L.; Kuo, T.T.; Bryant-Greenwood, P. Wong, L. L.; Tsai, N. Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro. The American Journal of Gastroenterology. Vol. 109. Num. 8. 2014. p. 1296-1298.

-Schilling, B.K.; Hammond, K.G.; Bloomer, R.J.; Presley, C.S.; Yates, C.R. Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men. BMC Pharmacology & Toxicology. Vol. 14. 2013. p. 14-52.

-Smith, T.B.; Staub, B.A.; Natarajan, G.M.; Lasorda, D.M.; Poornima, I.G. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Texas Heart Institute Journal. Vol.41. Num. 1. 2014. p. 70-72.

-Venhuis, B.; Kaste, D. Scientific Opinion on the Regulatory Status of 1,3-Dimethylamylamine (DMAA). European Journal of Food Research & Review. Vol. 2. Num. 4. 2012. p. 93-100.

-Vorce, S.P.; Holler, J.M.; Cawrse, B.M.; Magluilo, J. Dimethylamylamine: a drug causing positive immunoassay results for amphetamines. Journal of Analytical Toxicology. Vol. 35. Num. 3. 2011. p. 183-187.

-Young, C.; Oladipo, O.; Frasier, S.; Putko, R.; Chronister, S.; Marovich, M. Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d. Military Medicine. Vol. 177. Num. 12. 2012. p. 1450-1454.

-Zhang, Y.; Woods, R.M.; Breitbach, Z.S.; Armstrong, D.W. 1,3-Dimethylamylamine (DMAA) in supplements and geranium products: natural or synthetic?. Drug Testing and Analysis. Vol. 4. Num. 12. 2012. p. 986-990.

-Zovico, P.V.C.; Curty, V.M.; Cavatti, R.M.; Barauna, V.G. Suplementos Contendo DMAA: Mitos e Verdades. Revista Brasileira de Nutrição Esportiva. Vol.12. Num. 72. 2018. p. 443-462. Disponível em: <>

-Zovico, P.V.C.; Curty, V.M.; Leal, M.A.S.; Meira, E.F.; Dias, D.V.; Rodrigues, L.C. M.; Meyrelles, S.S.; Oliveira, E. M.; Vassalo, P. F. Barauna, V. G. Effects of controlled doses of Oxyelite Pro on physical performance in rats. Nutrition & Metabolism. Vol. 13. Num. 1. 2016. p. 13-90.

Como Citar
Zovico, P. V. C., Klippel, B. F., Santos, L. dos, Dias, D. V., & Barauna, V. G. (2019). Respostas cardiovasculares a diferentes formulações do suplemento OxyElite Pro. RBNE - Revista Brasileira De Nutrição Esportiva, 13(78), 182-194. Recuperado de
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