Effect of diferents doses of linseed oil treatment of dislipidemia in rats

  • Rui Gonçalves Marques Elias Universidade Estadual do Norte do Paraná (UENP)
  • Carlos Alexandre Molena-Fernandes Professor Doutor da Universidade Estadual do Paraná.
  • Augusto César Ferreira de Moraes Faculdade de Medicina da Universidade de São Paulo - Programa de pós-graduação.
  • Eliane Cristina de Andrade Gonçalves Acadêmica Educação Física -Bolsista PIBIQ
  • Roberto Kenji Nakamura Cuman Professor adjunto Universidade Estadual de Maringá-UEM.
Keywords: Flax seed oil, Metabolism, Wistar

Abstract

Objective: The objective of this study was to evaluate the effect of the treatment of linseed oil in different doses and days on hyperglycemia and dislipidemia with tritonWR 1339 induced in rats. Methods: The animals were divided into ten groups: the control group and the group treated for varying periods of 7, 14 or 21 days using doses of 50mg/kg, 100mg/kg, 500mg/kg e 750mg/kg. Results:The results showed that plasma levels of glucose, cholesterol and triglycerides were significantly increased 18 hours after the injection of triton WR 1339. The administration of linseed oil orally at doses of 50mg/kg and 100mg/kg, significantly decreased concentrations of cholesterol, triglycerides and glucose in rats with acute dyslipidemia. Conclusion:Our data indicates that flaxseed oil has an antilipemics effect only in low doses.

Author Biography

Rui Gonçalves Marques Elias, Universidade Estadual do Norte do Paraná (UENP)

Centro de Ciências da saúde - Jacarezinho

References

-Barreto, S.M.; e colaboradores. Análise da estratégia global para alimentação, atividade física e saúde, da Organização Mundial da Saúde. Epidemiol Serv Saúde. Vol. 14. Núm. 1. p. 41-68. 2005.

-Brasil. Ministério da Saúde. Vigilância de Doenças e Agravos não Transmissíveis (DAnT). Brasília. Disponível em: http://portal.saude.gov.br/portal/svs/area.cfm?id_area=448Acessado em 01/12/2010.

-Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. Vol. 285. p. 2486-2497. 2001.

-Ferrari, C.K.B.; Torres, E.A. Biochemical pharmacology of functional foods and prevention of chronic disease of aging. Biomed Pharmacother . Vol. 57. p. 251-260. 2003.

-Fickova, M.; Hubert, P.; Crémel, G.; Leray, C. Dietary (n-3) and (n-6) Polyunsaturated Fatty Acids Rapidly Modify Fatty Acid Composition and Insulin Effects in Rat Adipocytes. Journal of Nutrition. Vol. 512. Núm. 2. p. 512-519. 1998.

-Friedman, M.; Bayer, S.O. The mechanism underlying hypercholesterolemia induced by triton WR 1339. American Journal of Physiology. Vol. 190. p. 439-445. 1957.

-Frick, M. H.; Elo, O.; Haapa, K. “Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease,” The New England Journal of Medicine. p.1237-1245. 1987.

-Giron, M.D.; Sanchez, F.; Hortelano, P.; Periago, J.L.; Suarez, M.D.Effects of Dietary Fatty Acids on Lipid Metabolism in Streptozotocin-Induced Diabetic Rats. Metabolism. Vol. 48. p. 455-460. 1999.

-Harper, C.R.; Edwards, M.J.; De Filipis, A.P.; Jacobson, T.A. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr. Vol. 136. Núm. 1. p. 83-87. 2006.

-Harbige, L.S.; Pinto, E.; Xiang, M.; Leach, M.; Sharief, M.K. Pufa in the pathogenesis and treatment of patients with multiple sclerosis. Proc Nutr Soc. Vol. 67. p. E21. 2008.

-Kusama, H.; Nishiyama, M.; Ikeda, S. Pharmacological investigation of bezafibrate, ahypolipidemic agent. Effects od fezafibrate on normal and experimental hyperlipidemia in rats. Nippon Yakurigaku Zasshi. Vol. 92. p. 175-180. 1998.

-Lee, S.J.; Ko, J.H.; Lim, K.; Lim, K.T. 150 kDa glycoprotein isolated from Solanum nigrum Linne enhaces activities of detoxicant enzymes and lowers plasmic cholesterol in mouse. Pharmacology. Research. Vol. 51. Núm. 1. p. 399-408. 2005.

-Martin, C.; lmeida, V.V.; Ruiz, M.R.; Visentaineri, J.; Matshushita, M.; Souza, N.E.; Visentainer, J.V. Omega-3 and omega-6 polyunsaturated fatty acids: importance and accurrence in foods. Journal of Nutrition. Vol. 19. Núm. 5. p. 761-770. 2006.

-Mathur, K.S.; Singhal, S.S.; Sharma, R.D. Effect of Bengal Gram on experimentally induced high levels of cholesterol in tissues and serum in Albino Rats. Journal of Nutrition, Bethesda. Vol. 84. p. 201-204. 1964.

-Mccann, M.E.; Moore, J.N.; Carrick, J.B.; Barton M.H. Effect of intravenous infusion of omega-3 and omega-6 lipid emulsions on equine monocyte fatty acid composition and inflammatory mediator production in vitro. Shock. Vol. 14. p. 222-2288. 2000.

-Nicolosi, R.J.; Rogers, E.J.; Kritchevsky, D.; Scimeca, J.A.; Huthpj, P. Dietary conjugated linoleic acid reduces plasma and early aortic atherosclerosis in hypercholesterolemnic hamsters. Artery. Vol. 22. Núm. 1. p. 266-277. 1997.

-Oh, P.S.; Lee, S.J.; Li K.T. Hypolipidemic and antioxidative effects of the plant glycoprotein (36 kDa) from Rhus verniciflua stokes fruit in Triton WR-1339-induced hyperlipidemic mice. Bioscience Biotechnology Biochemical. Vol. 70. Núm. 3. p. 447-456. 2006.

-Patil, U.K.; Saraf, S.; Dixit, V.K. Hypolipidemic activity of seeds of Cassia tora Linn. Journal of Ethnopharmacology. Vol. 90. Núm. 2. p. 249-252. 2004.

-Simopoulos, A.P. Omega-3 fatty acids in wild plants nuts and seeds. Asia Pacific Journal Clinical Nutrition. Vol. 11. Núm. 3. p. 163-173. 2002.

-Soares, L. L.; Pacheco, J. T.; Brito, C. M.; Troina, A. A.; Boaventura, G.T.; Guzmán-Silva, M. A. Avaliação dos efeitos da semente de linhaça quando utilizada como fonte de proteína nas fases de crescimento e manutenção em ratos. Rev. Nutr. Vol. 22. Núm. 4. p. 483-491. 2009.

-Turatti, J.M. Óleos vegetais como fonte de alimentos funcionais. Óleos & Grãos. Vol. 56. p. 20-27. 2000.

-Yang, L.; Leung, K.Y.; Cao, Y.; Huang, Y.; Ratnayake, W.M.N.; Chen, Z.Y. Alpha -Linolenic acid but not conjugated linolenic acid is hypocholesterolaemic in hamsters. British Journal of Nutrition. Vol. 93. p. 433-438. 2005.

-Ziboh, V.A.; Miller, C.C.; Cho, Y. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes. Generation of antinflammatory and antiproleferative metabolites. American Journal of Clinical Nutrition. Vol. 7. p. 361-366. 2000.

Published
2012-12-09
How to Cite
Elias, R. G. M., Molena-Fernandes, C. A., Moraes, A. C. F. de, Gonçalves, E. C. de A., & Cuman, R. K. N. (2012). Effect of diferents doses of linseed oil treatment of dislipidemia in rats. RBNE - Brazilian Journal of Sports Nutrition, 6(35). Retrieved from https://www.rbne.com.br/index.php/rbne/article/view/309
Issue
Vol. 6 No. 35 (2012)
Section
Scientific Articles - Original

Authors who publish in this journal agree to the following terms:

  • Authors retain the copyright and grant the journal the right of first publication, with work simultaneously licensed under the Creative Commons Attribution License BY-NC which allows the sharing of the work with acknowledgment of the authorship of the work and initial publication in this journal.
  • Authors are authorized to enter into additional contracts separately for non-exclusive distribution of the version of the work published in this journal (eg, publishing in institutional repository or book chapter), with acknowledgment of authorship and initial publication in this journal.
  • Authors are allowed and encouraged to post and distribute their work online (eg, in institutional repositories or on their personal page) at any point before or during the editorial process, as this can bring about productive change as well as increase impact and impact. citation of published work (See The Effect of Free Access).