Interaction between hypocaloric and western diet in young rats exercised or not about metabolism and food preference
Abstract
Introduction: Adverse nutritional environment during the fetal period, lactation and infancy may favor occurrences of chronic diseases in the offspring. Objective: Analyze the effects of ingestion of a westernized diet on growth parameters, biochemistry, and food preference in the offspring of mothers fed a hypocaloric diet with or without physical activity. Methods. 40 rats were divided into 2 groups according to the diet: Control (n=20) and hypocaloric (n=20). The litters were composed of 8 pups, and at weaning 1 male pup from each litter was selected to compose new groups according to the westernized diet (C or H) and physical exercise (E and NE) composing the groups: CNE, CE, HNE and HE. Swimming was carried out from the weaning to the 62nd day of life and evaluated: Body weight, abdominal fat, biochemical parameters, food consumption and OGTT. Data expressed as mean, standard deviation, p<5% Results. Hypocaloric maternal diet caused 28% reduction in the weight of the pups at weaning; and the intake of the westernized diet post-weaning diet by the hypocaloric group equaled the groups in weight and length but did not modify food preference. Dyslipidemia was observed in HE and reduced body mass in CE compared to CNE at 63 days of life (CNE=306,1±57,8g; CE=235,5±31,5g; HNE=279,9±33,6g; HE=243,4±38,5g, p=0,0038). Conclusion. calorie restriction followed by westernized diet and exercise altered lipemic parameters, did not cause changes in dietary preference, and physical exercise reduced body mass in those fed a control diet before weaning, but not those fed a low-calorie diet before weaning.
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